In France, excess mortality among immigrants and their descendants during the first waves of the coronavirus disease (COVID-19) pandemic has been well documented and explained by material living conditions. The latter certainly played a major role, but the risk of death due to COVID-19 among ethnic minorities may also have been heightened by the higher prevalence of diabetes and obesity in these groups. To our knowledge, there are no data available in France on the differential prevalence rates of diabetes and obesity based on origin. Using the data of EpiCov, a representative survey of the population of metropolitan France, we aim to further knowledge of the prevalence of diabetes and obesity within the population and to draw attention to social inequalities in health that may be at play. Using an age-standardized approach that highlights excess risk not only among immigrants from Africa and Asia but also among their offspring as well as among people originating from French overseas departments and regions, we reveal significant origin-related disparities. These disparities are not entirely explained by individuals’ social positions, which suggests that other factors may be involved.